The ectoplasmic specialization (ES) is a testis‐specific, actin‐based hybrid anchoring and tight junction. It is confined to the interface between Sertoli cells at the blood–testis barrier, known as the basal ES, as well as between Sertoli cells and developing spermatids designated the apical ES. The ES shares features of adherens junctions, tight junctions and focal contacts. By adopting the best features of each junction type, this hybrid nature of ES facilitates the extensive junction‐restructuring events in the seminiferous epithelium during spermatogenesis. (...) For instance, the α6β1‐integrin–laminin 333 complex, which is usually limited to the cell–matrix interface in other epithelia to facilitate cell movement, is a putative apical ES constituent. Furthermore, JAM‐C and CAR, two tight junction integral membrane proteins, are also components of apical ES involving in spermatid orientation. We discuss herein the mechanisms that maintain the cross‐talk between ES and blood–testis barrier to facilitate cell movement and orientation in the seminiferous epithelium. BioEssays 29: 36–48, 2007. © 2006 Wiley Periodicals, Inc. (shrink)

Despite tributes paid to Fuller as an intellectual father of ADR, little attention has been paid within the ADR field to the broader interactionist vision that underlies Fuller’s discussion about process. A closer reading of Fuller’s study of mediation, however, reveals that he intended that study to substantiate his interactionist thesis about the nature of social ordering. He understood ordering to be generated by and to reflect a particular experience of social interaction. Fuller’s interactionist vision recognizes the creative, choice-making and (...) purposive dimensions of human reality, emphasizes participation as a normative criterion for institutional design, and gives rise to a pluralistic notion of power arrangements. It appears in Fuller’s thinking about process as a kind of dialectic and integrative mindset that pervades his means-ends analysis, functional analytical approach and his emphasis on institutional design. This interactionist vision has particular relevance for the practice and research of ADR, for example, in helping to develop a more integrative approach to process pluralism. (shrink)

The effectiveness of loss-framed versus gain-framed messages in attracting attention and influencing purchase intention among younger and older adults remains unclear. We tracked the eye movements of 92 younger (18–39 years) and 83 older adults (60–82 years) while they viewed 32 advertisements and reported their purchase intentions for each advertised product. The results showed that loss-framed (vs. gain-framed) product descriptions were associated with more attention but lower purchase intention intensity (i.e. intention magnitude), and the strength of these associations did not (...) differ significantly between age groups. Loss-framed (vs. gain-framed) product descriptions and enhanced attention were associated with greater purchase intention consistency (i.e. lower variance in purchase intention intensity), with the effect being stronger among older than younger adults. The overall findings support the attention-allocation model, which asserts that losses (or related information) can enhance on-task attention and decision consistency. However, the findings also reveal age-related differences suggesting that older adults, compared with younger adults, may be more influenced by loss messages in terms of purchase intention consistency but not attentional preference or purchase intention intensity in the advertising context. (shrink)

In this study, we investigated endorsement of two types of prescriptive views of aging, namely active aging and altruistic disengagement. The study comprised a large international sample of middle-aged and older adults, covering the age range from 40 to 90 years. Participants rated their personal endorsement of prescriptive views of active aging and altruistic disengagement targeting older adults in general. Findings showed that endorsement was higher for prescriptions for active aging than for prescriptions for altruistic disengagement. Age groups in the (...) sample differed regarding their endorsement of both prescriptive views of active aging and altruistic disengagement with older adults showing higher endorsement than middle-aged adults did. Prescriptive views of active aging and altruistic disengagement related positively to each other and to the superordinate social belief that older adults should not become a burden, which attests to their functional similarity. In contrast, prescriptive views of active aging and altruistic disengagement were associated with psychological adjustment in opposite ways, with endorsement of active aging being related to better adjustment outcomes such as life satisfaction and subjective health. Our findings highlight the internalization of prescriptive views of aging in older people and their implications for their development and well-being. (shrink)

Previous findings demonstrate that people often do not feel how they want to feel, supporting the distinction between “actual affect” and “ideal affect.” But are there certain activities that reduce the discrepancy between actual and ideal affect? Based on flow theory and socioemotional selectivity theory, we examined whether the discrepancy between people’s actual and ideal positive affect would be smaller during activities that were more conducive to flow (a state of intense absorption and concentration), pleasant, and familiar. In Study 1, (...) U.S. participants aged 17–79 (N = 393) reported their ideal affect and how they felt during activities with varying degrees of challenges and skills. For both low-arousal positive affect (LAP) and high-arousal positive affect (HAP), participants reported smaller actual-ideal affect discrepancies during flow-conducive activities (when skills matched challenges). Study 2 was a 14-day experience sampling study, in which Hong Kong participants aged 18–83 (Nindividual = 109) reported their momentary actual and ideal affect, and how pleasant and familiar their activities were (Nexperience = 3,815). Greater activity familiarity was associated with smaller discrepancies in actual-ideal LAP, while greater activity pleasantness was associated with smaller discrepancies in actual-ideal HAP. These findings provide insights on the activities that help people achieve their ideal affect more easily. (shrink)

Many events that humans and other species experience contain regularities in which certain elements within an event predict certain others. While some of these regularities involve tracking the co‐occurrences between temporally adjacent stimuli, others involve tracking the co‐occurrences between temporally distant stimuli (i.e., nonadjacent dependencies, NADs). Prior research shows robust learning of adjacent dependencies in humans and other species, whereas learning NADs is more difficult, and often requires support from properties of the stimulus to help learners notice the NADs. Here, (...) we report on seven experiments that examined NAD learning from various types of visual stimuli, exploring the effects of dynamic motion on adults' NAD learning from visual sequences involving human and nonhuman agents. We tested adults' NAD learning from visual sequences of human actions, object transformations, static images of human postures, and static images of an object in different postures. We found that dynamic motion aids the acquisition of NADs. We also found that learning NADs in sequences involving human agents is more robust compared to sequences involving nonhuman objects. We propose that dynamic motion and human agents both independently result in richer representations that provide a stronger signal for NAD learning. (shrink)

Scientific pluralism is an issue at the forefront of philosophy of science. This landmark work addresses the question, Can pluralism be advanced as a general, philosophical interpretation of science?

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Name der Zeitschrift: Jahrbuch für Wissenschaft und Ethik Jahrgang: 22 Heft: 1 Seiten: 65-86.

This essay introduces the volume Scientific Pluralism (Volume 19 of Minnesota Studies in Philosophy of Science). Varieties of recent pluralisms are surveyed, the difference between monism and pluralism vis a vis the sciences is clarified, and the authors’ notion of scientific pluralism is advanced.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Euripides' Escape-Tragedies: A Study of Helen, Andromeda, and Iphigenia among the TauriansHelene P. FoleyMatthew Wright. Euripides' Escape-Tragedies: A Study of Helen, Andromeda, and Iphigenia among the Taurians. Oxford: Oxford University Press, 2005. viii + 433 pp. Cloth, $125.Due to their putatively lighter tone, exotic foreign settings, and concluding "resolutions" of past misfortunes, Euripides' Helen, fragmentary Andromeda, and Iphigenia Among the Taurians (henceforth IT) have often (...) been described as proto-romances or tragi-comedies. Wright's study follows recent trends in defining ancient Greek dramatic genres above all through their performance context; he argues that the plays belong firmly in the tragic camp and develop serious philosophical and religious themes that deliberately leave their audience in a state of aporia. The plots of these plays share an escape from disaster/remote and threatening environments. Although we cannot firmly date IT, Wright tries to make the case that these apparently unique shared elements suggest that the plays were performed as a coherent trilogy in 412 B.C.E. The book does not [End Page 465] attempt to address in detail many aspects of these (relatively neglected) plays that have been extensively discussed by other critics. Instead Wright focuses on the plays' generic status, their possible mythical innovations, their remote settings, and their philosophy and theology.Although there are many unusual mythical elements in these plays, Wright makes a detailed case that Euripides most probably recombined elements previously known in the tradition to a novel effect, rather than inventing them. He casts considerable doubt on Stesichorus' palinode and Herodotus as origins for Euripides' innocent Egyptian Helen, however. Wright challenges previous assumptions by arguing that Euripides does not develop the plays' barbarian settings. Indeed, there is little ethnic or geographical detail beyond a few initial sketchy references, and the plays blur the differences between Greeks and barbarian "others." The Egyptians Proteus, Theoclymenus, and Theonoe are, genealogically speaking, Greek (183). After a lengthy discussion of the problems of defining philosophical elements in tragedy, Wright links the plays' extensive treatment of the unreliable nature of human language and knowledge of reality to discussions of comparable themes in the fragments of the Sophists, especially Gorgias and Democritus. Finally, Wright argues that the plays, by stressing the impossibility of understanding the divine forces that govern the universe, represent an unusually bleak theological picture. The dei ex machina that conclude Helen and IT belatedly outline mysterious divine patterns governing the confusing dramatic events, but humans can only repeatedly misinterpret their experience and name the divine forces governing their lives, erroneously in Wright's view, as tuche\.These issues, above all the themes of illusion and reality and the nature of divinity in the plays, have in fact been discussed before, but Wright attempts a fuller (with the exception of his attenuated discussion of ritual) and methodologically tighter discussion. This represents both the book's strength and weakness. Without its exhaustive review of dated and (putatively) weakly argued earlier critical views, the book could, and in my view ideally should, have made its positive case more forcefully in half the length. At the same time, by failing to engage with important earlier treatments of central topics, Wright leaves the reader with the impression that scholarly work on these issues is far less nuanced than it has in fact been. To give a few examples that he neglects altogether, his discussion of Aristophanes' parody of Euripides in Thesmophoriazusae (120, n. 196; see also 50–51) does not take advantage of Zeitlin's seminal article on the topic ("Travesties of Gender and Genre in Aristophanes' Thesmophoriazusae," published most recently in her Playing the Other: Gender and Society in Classical Greek Literature [Chicago, 1996], 375–416); he does not make use of John H. Finley's extensive study of Euripides, Thucydides, and the sophists (Three Essays on Thucydides, [Cambridge, Mass., 1967]); other important methodologically sophisticated work on philosophy and tragedy, such as that of Mary Whitlock Blundell (Helping Friends and Harming Enemies: A Study in Sophocles and Greek Ethics [Cambridge, 1989]) or Christopher Gill (Personality in Greek Epic, Tragedy, and Philosophy: The Self in Dialogue [Oxford, 1996]), does not even appear in the notes. [End Page 466... (shrink)

ABSTRACTDifficulties with inhibiting fear have been associated with the emergence of anxiety problems and poor response to cognitive–behavioural treatment. Fear inhibition problems measured using experimental paradigms involving aversive stimuli may be inappropriate for vulnerable samples and may not capture fear inhibition problems evident in everyday life. We present the Fear Inhibition Questionnaire, a self-report measure of fear inhibition abilities. We assess the FIQ’s factor structure across two cultures and how well it correlates with fear inhibition indices derived experimentally. Adolescent participants (...) from Hong Kong and England completed the FIQ, with the English participants also completing a conditioning and extinction task to assess fear inhibition problems. Across both cultures, the FIQ showed a single factor structure and low FIQ scores, or worse fear inhibition problems, were associated with self-reports of heightened anxiety. Correlation of FIQ scores with experimental indices, whi... (shrink)

Decisions about how and where they deliver their baby are extremely important to pregnant women. There are very strong ethical norms that women’s autonomy should be respected, and that plans around birth should be personalised. However, there appear to be profound challenges in practice to respecting women’s choices in pregnancy and labour. Choices carry risks and consequences—to the woman and her child; also potentially to her caregivers and to other women.What does it mean for women’s autonomy to be respected in (...) obstetrics? How should health professionals respond to refusals of treatment or requests for care outside normal guidelines? What are the ethical limits to autonomy? In this clinical ethics round table, service users, midwives, obstetricians, philosophers and ethicists respond to two hypothetical cases drawn from real-life scenarios. (shrink)

In the present contribution we look at the legacy of Hilbert's programme in some recent developments in mathematics. Hilbert's ideas have seen new life in generalised and relativised forms by the hands of proof theorists and have been a source of motivation for the so--called reverse mathematics programme initiated by H. Friedman and S. Simpson. More recently Hilbert's programme has inspired T. Coquand and H. Lombardi to undertake a new approach to constructive algebra in which strong emphasis is laid on (...) the use of finite methods. The main aim is to eliminate the ideal objects and in so doing obtain more elementary and informative proofs. We survey some work in commutative algebra---mainly about and around the Zariski spectrum and the Krull dimension of a commutative ring---which witnesses the feasibility of such a revised Hilbert's programme. (shrink)

In this article, Hannah Arendt's concept of action will be used to problematize current transformations of the health care sector and examine some responses by ethicists in light of those transformations. The sphere of human interaction that should typify health care work is identified as an action of unpredictable praxis in contrast to controllable procedures and techniques which increasingly take place in the health care sector.

In the last decade, reading research has seen a paradigmatic shift. A new wave of computational models of orthographic processing that offer various forms of noisy position or context-sensitive coding have revolutionized the field of visual word recognition. The influx of such models stems mainly from consistent findings, coming mostly from European languages, regarding an apparent insensitivity of skilled readers to letter order. Underlying the current revolution is the theoretical assumption that the insensitivity of readers to letter order reflects the (...) special way in which the human brain encodes the position of letters in printed words. The present article discusses the theoretical shortcomings and misconceptions of this approach to visual word recognition. A systematic review of data obtained from a variety of languages demonstrates that letter-order insensitivity is neither a general property of the cognitive system nor a property of the brain in encoding letters. Rather, it is a variant and idiosyncratic characteristic of some languages, mostly European, reflecting a strategy of optimizing encoding resources, given the specific structure of words. Since the main goal of reading research is to develop theories that describe the fundamental and invariant phenomena of reading across orthographies, an alternative approach to model visual word recognition is offered. The dimensions of a possible universal model of reading, which outlines the common cognitive operations involved in orthographic processing in all writing systems, are discussed. (shrink)

Background: Electroconvulsive therapy is one of the most effective treatments for major depressive disorder. Recently, there has been increasing attention to evaluate the effect of ECT on resting-state functional magnetic resonance imaging. This study aims to compare rs-fMRI of depressive disorder patients with healthy participants, investigate whether pre-ECT dynamic functional network connectivity network estimated from patients rs-fMRI is associated with an eventual ECT outcome, and explore the effect of ECT on brain network states.Method: Resting-state functional magnetic resonance imaging data were (...) collected from 119 patients with depression or depressive disorder, and 61 healthy participants, with an age mean of 52.25 years old. The pre-ECT and post-ECT Hamilton Depression Rating Scale were 25.59 ± 6.14 and 11.48 ± 9.07, respectively. Twenty-four independent components from default mode and cognitive control network were extracted, using group-independent component analysis from pre-ECT and post-ECT rs-fMRI. Then, the sliding window approach was used to estimate the pre-and post-ECT dFNC of each subject. Next, k-means clustering was separately applied to pre-ECT dFNC and post-ECT dFNC to assess three distinct states from each participant. We calculated the amount of time each subject spends in each state, which is called “occupancy rate” or OCR. Next, we compared OCR values between HC and DEP participants. We also calculated the partial correlation between pre-ECT OCRs and HDRS change while controlling for age, gender, and site. Finally, we evaluated the effectiveness of ECT by comparing pre- and post-ECT OCR of DEP and HC participants.Results: The main findings include depressive disorder patients had significantly lower OCR values than the HC group in state 2, where connectivity between cognitive control network and default mode network was relatively higher than other states, Pre-ECT OCR of state, with more negative connectivity between CCN and DMN components, is linked with the HDRS changes. This means that those DEP patients who spent less time in this state showed more HDRS change, and The post-ECT OCR analysis suggested that ECT increased the amount of time DEP patients spent in state 2.Conclusion: Our finding suggests that dynamic functional network connectivity features, estimated from CCN and DMN, show promise as a predictive biomarker of the ECT outcome of DEP patients. Also, this study identifies a possible underlying mechanism associated with the ECT effect on DEP patients. (shrink)